Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | JAK1 | P23458 | 3/20 | 0.57 |
| ▸ | TYK2 | P29597 | 3/20 | 0.57 |
| ▸ | JAK3 | P52333 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 3/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | CCNK | O75909 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CCND3 | P30281 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344180 | 0.87 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2TDP1AURKA | |
| SCHEMBL3350959 | 0.83 | SMN1; SMN2 (0.55) | JAK2NPC1RAB9ASMN1; SMN2AURKA | |
| SCHEMBL13310863 | 0.83 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2TDP1AURKA | |
| SCHEMBL3450597 | 0.83 | TDO2 (0.52) | NPC1RAB9ASMN1; SMN2TDP1AURKA | |
| SCHEMBL3456615 | 0.81 | NPC1 (0.56) | JAK2NPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL13312654 | 0.79 | PAK1 (0.46) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL3451371 | 0.78 | FGFR1 (0.45) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL3449190 | 0.78 | NPC1 (0.52) | JAK2JAK3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18330249 | 0.78 | TDP1 (0.73) | JAK3SMN1; SMN2TDP1AURKAAURKB | |
| SCHEMBL3451632 | 0.77 | TDO2 (0.47) | JAK2JAK1TYK2JAK3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | JAK2 1093/4885JAK1 2067/4885TYK2 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.