Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.35 |
| ▸ | TESK1 | Q15569 | 1/20 | 0.35 |
| ▸ | TESK2 | Q96S53 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579872 | 0.80 | ALDH1A1 (0.47) | KMT2AALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL22258774 | 0.76 | CCNE2 (0.54) | KMT2AALDH1A1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL13314759 | 0.73 | MCL1 (0.54) | KMT2AALDH1A1SMN1; SMN2CYP1A2HDAC3 | |
| SCHEMBL20161590 | 0.71 | IRAK4 (0.40) | ALDH1A1SMN1; SMN2ROCK2HDAC1HDAC8 | |
| SCHEMBL13314753 | 0.70 | HTT (0.41) | KMT2AALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL24780233 | 0.70 | IRAK4 (0.36) | KMT2AALDH1A1GAASMN1; SMN2HDAC3 | |
| SCHEMBL3584065 | 0.68 | HSP90AA1 (0.39) | ALDH1A1GAAKDM4ECYP1A2 | |
| SCHEMBL8262317 | 0.68 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CCNE2CCNE1CDK2 | |
| SCHEMBL29132841 | 0.67 | NISCH (0.37) | KMT2AALDH1A1KDM4ECYP1A2CHUK | |
| SCHEMBL30703605 | 0.67 | NISCH (0.37) | KMT2AALDH1A1KDM4ECYP1A2CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160324-A1 | PYRAZOLE DERIVATIVES AS THAT MODULATE THE ACTIVITY OF CDK, GSK AND AURORA KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100160324-A1 | PYRAZOLE DERIVATIVES AS THAT MODULATE THE ACTIVITY OF CDK, GSK AND AURORA KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160324-A1 | PYRAZOLE DERIVATIVES AS THAT MODULATE THE ACTIVITY OF CDK, GSK AND AURORA KINASES | CDK1, CDK3, CDK13 | KMT2A 586/4885ALDH1A1 3914/4885GAA 4390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.