Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13296539 | 1.00 | CASP3 (0.43) | CASP3KMT2AEPHX2PIN1MDM4 | |
| SCHEMBL13315053 | 0.92 | CASP3 (0.46) | CASP3KMT2AEPHX2PIN1MDM4 | |
| SCHEMBL13296521 | 0.92 | CASP3 (0.46) | CASP3KMT2AEPHX2PIN1MDM4 | |
| SCHEMBL13315113 | 0.91 | PTPN1 (0.43) | — | |
| SCHEMBL13296524 | 0.90 | PTPN1 (0.42) | CASP3 | |
| SCHEMBL13296511 | 0.89 | CASP3 (0.41) | CASP3 | |
| SCHEMBL13296518 | 0.87 | FDFT1 (0.44) | CASP3 | |
| SCHEMBL13296529 | 0.87 | CASP3 (0.39) | CASP3KMT2APIN1MDM4TP53 | |
| SCHEMBL13296517 | 0.85 | SLC17A5 (0.40) | CASP3MDM4TP53 | |
| SCHEMBL13296527 | 0.84 | PTPN1 (0.44) | CASP3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737293-B2 | Amide forming chemical ligation | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090069536-A1 | Amide Forming Chemical Ligation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-03-12 | — | — | US | disclosed |
| US-20070060773-A1 | Amide forming chemical ligation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069536-A1 | Amide Forming Chemical Ligation | CPS1, GLUL, PCCA | CASP3 4251/4885KMT2A 151/4885EPHX2 2741/4885 |
| US-20070060773-A1 | Amide forming chemical ligation | CPS1, GLUL, PCCA | CASP3 4251/4885KMT2A 151/4885EPHX2 2741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.