Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 16/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | PDE5A | O76074 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580233 | 0.91 | ABCG2 (0.63) | ABCG2MAPTTP53ABCB1SMN1; SMN2 | |
| SCHEMBL3575009 | 0.86 | GRM4 (0.45) | ABCG2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4864882 | 0.76 | ABCG2 (0.73) | ABCG2MAPTTP53LMNAABCC1 | |
| SCHEMBL29395013 | 0.76 | TGFBR1 (0.71) | ABCG2MAPTTP53LMNAMEN1 | |
| SCHEMBL13154697 | 0.76 | TGFBR1 (0.71) | ABCG2MAPTTP53LMNAMEN1 | |
| SCHEMBL882601 | 0.75 | ABCG2 (0.60) | ABCG2MAPTTP53LMNAABCB1 | |
| SCHEMBL786325 | 0.75 | ABCG2 (0.61) | ABCG2MAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL1062778 | 0.75 | TGFBR1 (0.71) | ABCG2MAPTTP53LMNAABCB1 | |
| SCHEMBL3587569 | 0.74 | TGFBR1 (0.69) | ABCG2MEN1KMT2APDE5AAURKB | |
| SCHEMBL785611 | 0.74 | ABCG2 (0.60) | ABCG2MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137324-A1 | RHO-KINASE INHIBITORS | NAGARATHNAM DHANAPHALAN | 2010-06-03 | — | — | US | disclosed |
| US-20100137324-A1 | RHO-KINASE INHIBITORS | NAGARATHNAM DHANAPHALAN | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137324-A1 | RHO-KINASE INHIBITORS | CIT, ROCK1, ROCK2 | ABCG2 3107/4885MAPT 2039/4885TP53 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.