Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 4/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316637 | 0.90 | METTL3 (0.33) | PDE3BPDE3AKDM4EALDH1A1GAA | |
| SCHEMBL3621739 | 0.87 | METTL3 (0.38) | KDM4EALDH1A1MRGPRX4KMT2ATP53 | |
| SCHEMBL3627969 | 0.86 | PDE3B (0.41) | PDE3BPDE3AKDM4EALDH1A1GAA | |
| SCHEMBL13316635 | 0.83 | PDE3B (0.36) | PDE3BPDE3AKDM4EALDH1A1GAA | |
| SCHEMBL13349670 | 0.80 | PCSK9 (0.33) | ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3620368 | 0.80 | PDE3B (0.43) | PDE3BPDE3AKDM4EALDH1A1GAA | |
| SCHEMBL13316622 | 0.78 | PDE3B (0.41) | PDE3BPDE3AKDM4EALDH1A1GAA | |
| SCHEMBL13316644 | 0.77 | PDE3B (0.41) | PDE3BPDE3AKDM4EALDH1A1GAA | |
| SCHEMBL3625716 | 0.77 | PDE3B (0.41) | PDE3BPDE3AKDM4EALDH1A1GAA | |
| SCHEMBL13316621 | 0.77 | PDE3B (0.40) | PDE3BPDE3AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |