Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 3/20 | 0.33 |
| ▸ | MDM4 | O15151 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624007 | 0.89 | PDE3B (0.37) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL13316636 | 0.83 | PDE3B (0.40) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL13316637 | 0.77 | METTL3 (0.33) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3620368 | 0.71 | PDE3B (0.43) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3621739 | 0.71 | METTL3 (0.38) | KDM4EALDH1A1TP53MRGPRX4 | |
| SCHEMBL3627969 | 0.70 | PDE3B (0.41) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL13316622 | 0.69 | PDE3B (0.41) | PDE3BPDE3AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL13316642 | 0.69 | PDE3B (0.38) | PDE3BPDE3AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1048227 | 0.69 | METTL3 (0.50) | PDE3BPDE3AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1050745 | 0.69 | METTL3 (0.50) | PDE3BPDE3AL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |