Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316629 | 0.84 | MPO (0.36) | MPOMEN1KMT2ARXRAGRIN1 | |
| SCHEMBL13316614 | 0.79 | CYP3A4 (0.42) | MPORXRAGRIN1GRIN2BAKR1B1 | |
| SCHEMBL13316625 | 0.75 | MPO (0.41) | MPOKMT2ARXRAGRIN1GRIN2B | |
| SCHEMBL2744577 | 0.75 | GRIA1 (0.42) | MPOMEN1KMT2AMAPTAKR1B1 | |
| SCHEMBL11940512 | 0.73 | MEN1 (0.41) | MEN1KMT2AMAPT | |
| SCHEMBL30117237 | 0.71 | KMT2A (0.44) | MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3673652 | 0.71 | KMT2A (0.44) | MEN1KMT2AMAPTKDM4E | |
| SCHEMBL1762618 | 0.69 | MEN1 (0.43) | MEN1KMT2AMAPT | |
| SCHEMBL13349673 | 0.69 | MPO (0.32) | MPOMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13349708 | 0.69 | CASR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |