Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316638 | 0.84 | MPO (0.34) | MPOAKR1B1TP53MDM2KDM4E | |
| SCHEMBL13316625 | 0.81 | MPO (0.41) | MPOAKR1B1KMT2ASGMS2RXRA | |
| SCHEMBL2744577 | 0.77 | GRIA1 (0.42) | MPOAKR1B1MEN1ALDH1A1KMT2A | |
| SCHEMBL13316614 | 0.75 | CYP3A4 (0.42) | MPOAKR1B1SGMS2RXRAGRIN1 | |
| SCHEMBL13349673 | 0.74 | MPO (0.32) | MPOKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL21224318 | 0.69 | MEN1 (0.34) | MEN1KMT2A | |
| SCHEMBL13316673 | 0.68 | PDE10A (0.39) | MPOKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL3678639 | 0.67 | MEN1 (0.35) | KDM4EMEN1KMT2A | |
| SCHEMBL14252395 | 0.64 | AKR1B1 (0.38) | MPOAKR1B1MEN1ALDH1A1KMT2A | |
| SCHEMBL8067746 | 0.64 | ENPP2 (0.44) | KDM4EMEN1ALDH1A1KMT2AGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |