Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.53 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | LYN | P07948 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331695 | 0.90 | AURKB (0.61) | FGFR1DDR2NTRK1AURKBFLT3 | |
| SCHEMBL1330301 | 0.83 | AXL (0.60) | FGFR1DDR2NTRK1AURKBFLT3 | |
| SCHEMBL1331716 | 0.82 | MAPK1 (0.57) | FGFR1DDR2NTRK1AURKBFLT3 | |
| SCHEMBL1331849 | 0.81 | MAPK1 (0.56) | FGFR1DDR2NTRK1AURKBFLT3 | |
| SCHEMBL1332041 | 0.80 | KDR (0.69) | FGFR1DDR2NTRK1AURKBFLT3 | |
| SCHEMBL1331850 | 0.79 | FGFR1 (0.64) | FGFR1DDR2NTRK1AURKBAXL | |
| SCHEMBL1330136 | 0.79 | AXL (0.62) | FGFR1DDR2AURKBAXLKDR | |
| SCHEMBL1331406 | 0.79 | FGFR1 (0.58) | FGFR1DDR2NTRK1AURKBFLT3 | |
| SCHEMBL1330486 | 0.79 | KDR (0.62) | FGFR1DDR2NTRK1AURKBFLT3 | |
| SCHEMBL1330237 | 0.79 | FGFR1 (0.70) | FGFR1DDR2NTRK1AURKBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | FGFR1 227/4885DDR2 1265/4885NTRK1 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.