Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.66 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636328 | 0.84 | ADORA1 (0.62) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL15623910 | 0.82 | ADORA1 (0.47) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13317093 | 0.80 | ADORA1 (0.57) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13317079 | 0.80 | POLB (0.48) | ADORA1ADORA2BKDM4EALDH1A1 | |
| SCHEMBL13317113 | 0.79 | ADORA1 (0.46) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3557732 | 0.79 | ADORA1 (0.56) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13317101 | 0.79 | ADORA1 (0.46) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14447461 | 0.77 | ALDH1A1 (0.46) | ADORA1KDM4EALDH1A1ADORA2AGAA | |
| SCHEMBL13317100 | 0.77 | TOP2A (0.47) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL19233749 | 0.76 | ADORA1 (0.51) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401838-B1 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-26 | — | — | EP | disclosed |
| US-7732437-B2 | Use of anti-histaminics for acute reduction of elevated intracranial pressure | JANSSEN PHARMACEUTICA, NV. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-7732437-B2 | Use of anti-histaminics for acute reduction of elevated intracranial pressure | JANSSEN PHARMACEUTICA, NV. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-7476662-B2 | Substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-13 | — | — | US | disclosed |
| US-7476662-B2 | Substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-13 | — | — | US | disclosed |
| EP-1451196-B1 | The use of substituted tetracyclic imidazole derivatives as anti-histaminics | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | EP | disclosed |