Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13317080 | 0.82 | ADORA1 (0.66) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13317079 | 0.78 | POLB (0.48) | ADORA1ADORA2BKDM4EALDH1A1POLB | |
| SCHEMBL13317113 | 0.75 | ADORA1 (0.46) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13317101 | 0.75 | ADORA1 (0.46) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14447563 | 0.74 | APEX1 (0.50) | KDM4EALDH1A1 | |
| SCHEMBL13317100 | 0.73 | TOP2A (0.47) | ADORA1ADORA2BKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13317105 | 0.73 | LMNA (0.43) | ADORA1KDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14447461 | 0.73 | ALDH1A1 (0.46) | ADORA1KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13317094 | 0.72 | ALDH1A1 (0.45) | ADORA1ADORA2BALDH1A1HPGDADORA2A | |
| SCHEMBL13317112 | 0.71 | MMP9 (0.46) | ADORA1KDM4EALDH1A1CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401838-B1 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-26 | — | — | EP | disclosed |