Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.56 |
| ▸ | FAAH | O00519 | 4/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249803 | 0.93 | MGLL (0.56) | MGLLFAAHTRPV1 | |
| SCHEMBL13328913 | 0.91 | MGLL (0.47) | MGLLFAAHTRPV1 | |
| SCHEMBL13328918 | 0.90 | MGLL (0.42) | MGLLFAAHTRPV1 | |
| SCHEMBL13328927 | 0.89 | MGLL (0.42) | MGLLFAAHTRPV1 | |
| SCHEMBL13328962 | 0.88 | MGLL (0.41) | MGLLFAAHTRPV1 | |
| SCHEMBL13328920 | 0.88 | MGLL (0.41) | MGLLFAAHTRPV1 | |
| SCHEMBL13328926 | 0.88 | PRLHR (0.44) | MGLL | |
| SCHEMBL13328953 | 0.87 | MGLL (0.40) | MGLL | |
| SCHEMBL13328946 | 0.86 | MEN1 (0.42) | MGLL | |
| SCHEMBL13249795 | 0.83 | MGLL (0.47) | MGLLFAAHTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318751-B2 | Pyrimidinone derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20100113487-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113487-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GPR180, GPR17 | MGLL 1341/4885FAAH 2045/4885TRPV1 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.