Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13330218 | 0.89 | ALDH1A1 (0.41) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13329839 | 0.89 | KDM4E (0.44) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13330007 | 0.89 | ALDH1A1 (0.40) | ALDH1A1PIK3CAGAAKDM4EMAPT | |
| SCHEMBL13330056 | 0.84 | ALDH1A1 (0.38) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13329825 | 0.83 | KDM4E (0.38) | ALDH1A1GAAKDM4EMAPTHPGD | |
| SCHEMBL13329799 | 0.83 | ACVR1 (0.40) | ALDH1A1GAAKDM4EMAPTHPGD | |
| SCHEMBL13329850 | 0.80 | CDC7 (0.55) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13330055 | 0.78 | RAB9A (0.41) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13330000 | 0.78 | PDE5A (0.36) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL13329828 | 0.76 | DGAT1 (0.36) | ALDH1A1PIK3CDKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010067123-A1 | 2- (PIPERIDIN-1-YL) -4-HETEROCYCLYL-THIAZOLE-5-CARBOXYLIC ACID DERIVATIVES AGAINST BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2010-06-17 | — | — | WO | disclosed |