Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WHR1 | P49842 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170380 | 0.91 | WHR1 (0.47) | WHR1ADRA1AADRA1B | |
| SCHEMBL2170465 | 0.89 | RET (0.43) | WHR1RETPDE5AADRA1AADRA1B | |
| SCHEMBL2170876 | 0.88 | WHR1 (0.43) | WHR1RETPDE5AADRA1AADRA1B | |
| SCHEMBL2172854 | 0.88 | PDE5A (0.47) | WHR1RETPDE5AHDAC1HDAC6 | |
| SCHEMBL2170496 | 0.86 | WHR1 (0.45) | WHR1ADRA1AADRA1BKMT5A | |
| SCHEMBL2171175 | 0.86 | WHR1 (0.45) | WHR1ADRA1AADRA1BKMT5A | |
| SCHEMBL3319375 | 0.86 | WHR1 (0.45) | WHR1ADRA1AADRA1BKMT5A | |
| SCHEMBL3318301 | 0.86 | WHR1 (0.40) | WHR1RETPDE5AADRA1AADRA1B | |
| SCHEMBL3318949 | 0.84 | SLC2A1 (0.44) | RETPDE5A | |
| SCHEMBL2170268 | 0.84 | PDGFRB (0.45) | WHR1ADRA1AADRA1BPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318749-B2 | Quinazoline derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20100125078-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125078-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | SLC6A3, OPRK1, HTR3A | WHR1 4280/4885RET 342/4885PDE5A 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.