SCHEMBL133335

SCHEMBL133335

FC(F)(F)c1cc[c]nc1

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
TSHR P16473 1/20 0.35
KMT2A Q03164 1/20 0.34
KIF11 P52732 2/20 0.33
TRPV4 Q9HBA0 1/20 0.32
BACE1 P56817 1/20 0.31
METAP2 P50579 1/20 0.31
NOS3 P29474 1/20 0.30
NOS2 P35228 1/20 0.30
SCN2A Q99250 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15093659 0.86
SCHEMBL602673 0.82
SCHEMBL5762225 0.82
SCHEMBL603804 0.82
SCHEMBL1435744 0.77 KIF11 (0.50) ALDH1A1KIF11SCN2A
SCHEMBL534299 0.76 TSHR (0.33) TSHRKIF11
SCHEMBL1436093 0.76 RXRA (0.40) SCN2A
SCHEMBL744997 0.73
SCHEMBL3997079 0.72 SOD1 (0.36) ALDH1A1
SCHEMBL744561 0.72 SCN2A (0.49) ALDH1A1KIF11SCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2714 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115611856-B Piperidine derivative and pharmaceutical composition, preparation method and application thereof 宜昌人福药业有限责任公司 2024-07-05 CN claimed
US-20240208902-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-06-27 US claimed
CN-114621209-B 1,2, 3-Thiadiazole acetonitrile derivatives, and preparation method and application thereof 南开大学 2024-06-14 CN claimed
CN-118164921-A Propyl phenoxypropionate compound, preparation method thereof and application thereof as herbicide 山东德瑞克化工科技有限公司 2024-06-11 CN claimed
WO-2024118801-A1 LINEAR HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS PROTEGO BIOPHARMA, INC. (US) 2024-06-06 WO claimed
EP-4347568-A1 HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS Protego Biopharma, Inc. (US) 2024-04-10 EP claimed
CN-117836296-A Pyrazolopyridone compounds 百济神州有限公司 2024-04-05 CN claimed
EP-4345096-A1 PIPERIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF Yichang Humanwell Pharmaceutical Co., Ltd. (CN) 2024-04-03 EP claimed
US-20240092757-A1 HETEROARYL DIAMIDE IRE1/XBP1s ACTIVATORS THE SCRIPPS RESEARCH INSTITUTE 2024-03-21 US claimed
CN-117642402-A Spiropiperidine ring derivative and pharmaceutical composition, preparation method and application thereof 宜昌人福药业有限责任公司 2024-03-01 CN claimed
US-4994473-A For plants ICI AMERICAS INC. (US) 1991-02-19 US claimed
EP-0350237-A2 Triazole insecticides SCHERING AGROCHEMICALS LIMITED (GB) 1990-01-10 EP claimed
EP-0319100-A2 Process for the preparation of substituted phenoxy propanoic acids SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1989-06-07 EP claimed
EP-0242081-A1 Fungicides ZENECA LIMITED (GB) 1987-10-21 EP claimed
US-4601748-A 2-phenoxy propionic acid derivatives of pentite, process for the production of these compounds as well as compositions containing the same having herbicidal effectiveness SCHERING AKTIENGESELLSCHAFT (DE) 1986-07-22 US claimed
US-4554014-A O-Aryloxyphenoxyacyl-α-N,N,-dialkylaminooximes and herbicidal methods of use STAUFFER CHEMICAL COMPANY (US) 1985-11-19 US claimed
US-4470841-A Certain herbicidal phosphonates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-09-11 US claimed
EP-0073040-A2 Organic phosphorus compounds, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-03-02 EP claimed
US-4246419-A SULFONAMIDE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-01-20 US claimed
EP-0003648-A2 4-Aryloxy-substituted phenoxypropionamide derivatives useful as herbicides, compositions containing them, and processes for making them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1979-08-22 EP claimed