Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10827979 | 0.93 | AGER (0.53) | AGERHTTTDP1HPGDPOLB | |
| SCHEMBL14490855 | 0.89 | AGER (0.60) | AGERHTTHPGDPOLBKDM4E | |
| SCHEMBL130152 | 0.88 | HTT (0.72) | AGERHTTHPGDPOLBKDM4E | |
| SCHEMBL6962669 | 0.88 | AGER (0.58) | AGERHTTHPGDPOLBKDM4E | |
| SCHEMBL9835503 | 0.87 | KMT2A (0.54) | AGERHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7368723 | 0.86 | KDM4E (0.49) | AGERHTTTDP1HPGDPOLB | |
| SCHEMBL10872846 | 0.85 | HTT (0.51) | AGERHTTTDP1HPGDPOLB | |
| SCHEMBL14490806 | 0.85 | HTT (0.60) | AGERHTTHPGDPOLBKDM4E | |
| SCHEMBL20920574 | 0.85 | AGER (0.62) | AGERHTTHPGDPOLBKDM4E | |
| SCHEMBL2337780 | 0.84 | HTT (0.51) | HTTTDP1HPGDPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 162 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119822987-A | Preparation method of 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester | 苏州诚和医药化学有限公司 | 2025-04-15 | — | — | CN | claimed |
| CN-117843520-A | Methoxychlor-pram intermediate and preparation method and application thereof | 常熟泓德生物科技有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-116102451-A | Preparation process of metoclopramide | 内蒙古康普药业有限公司 | 2023-05-12 | — | — | CN | claimed |
| US-20060110743-A1 | Drug evolution: drug design at hot spots | KONISHI YASUO | 2006-05-25 | — | — | US | claimed |
| WO-2002095393-A2 | DRUG EVOLUTION: DRUG DESIGN AT HOT SPOTS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2002-11-28 | — | — | WO | claimed |
| CN-116102451-B | Methoxychlor-pup Process for the preparation of amines | 内蒙古康普药业有限公司 | 2025-10-28 | — | — | CN | disclosed |
| CN-119822987-A | Preparation method of 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester | 苏州诚和医药化学有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-119039171-B | Industrial production of hydrochloric acid Methoxychlor-pram process | 广州市桐晖药业有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119039171-A | Industrial production of hydrochloric acid Methoxychlor-pram process | 广州市桐晖药业有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-117843520-A | Methoxychlor-pram intermediate and preparation method and application thereof | 常熟泓德生物科技有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-116102451-A | Preparation process of metoclopramide | 内蒙古康普药业有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-116102451-A | Preparation process of metoclopramide | 内蒙古康普药业有限公司 | 2023-05-12 | — | — | CN | disclosed |
| US-4267175-A | FOR USE AS AN ANTIEMETIC, AND TREATMENT FOR GASTROINTESTINAL DISORDERS | BEECHAM GROUP LIMITED (GB) | 1981-05-12 | — | — | US | disclosed |
| US-4213983-A | Treating gastro-intestinal disorders and emesis with n-(heterocyclic substituted) benzamides | BEECHAM GROUP LIMITED (GB) | 1980-07-22 | — | — | US | disclosed |
| EP-0013138-A1 | Azabicycloalkyl derivatives, a process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1980-07-09 | — | — | EP | disclosed |
| US-4207327-A | N-(4-Pyrazolidinyl)benzamides and their amino precursors | A. H. ROBINS COMPANY, INC. (US) | 1980-06-10 | — | — | US | disclosed |
| US-4163789-A | Anti-psychotic (cycloalkenylalkylpiperidino) benzamides | ANPHAR, S.A. (ES) | 1979-08-07 | — | — | US | disclosed |
| US-4138492-A | FOR TREATMENT OF GASTROINTESTINAL DISORDERS | ANPHAR, S.A. (ES) | 1979-02-06 | — | — | US | disclosed |
| US-3966957-A | Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-06-29 | — | — | US | disclosed |
| US-3963745-A | Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-06-15 | — | — | US | disclosed |