Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | CLK3 | P49761 | 3/20 | 0.47 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | WNT1 | P04628 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13362640 | 0.90 | DYRK1A (0.48) | DYRK1ACLK2CLK3MAP4K3MAP4K1 | |
| SCHEMBL13336098 | 0.88 | DYRK1A (0.44) | DYRK1ACLK2CLK3MAP4K3MAP4K1 | |
| SCHEMBL13251937 | 0.87 | ALK (0.49) | DYRK1ACLK2CLK3MAP4K3MAP4K1 | |
| SCHEMBL13336313 | 0.83 | JAK1 (0.49) | DYRK1ACLK2CLK3CDK1AURKA | |
| SCHEMBL12671430 | 0.82 | MAP4K1 (0.46) | DYRK1ACLK2CLK3MAP4K3MAP4K1 | |
| SCHEMBL13363122 | 0.82 | BRAF (0.43) | DYRK1ACLK2CLK3 | |
| SCHEMBL13225919 | 0.80 | MAP4K1 (0.42) | DYRK1AMAP4K3MAP4K1AURKBWNT1 | |
| SCHEMBL1571320 | 0.80 | MAP4K1 (0.44) | MAP4K3MAP4K1CDK2IGF1RCCNA2 | |
| SCHEMBL13225918 | 0.80 | MET (0.46) | DYRK1ACLK2CLK3MAP4K3MAP4K1 | |
| SCHEMBL13362991 | 0.79 | MAP4K1 (0.45) | MAP4K3MAP4K1CDK2IGF1RCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | DYRK1A 1286/4885CLK2 548/4885CLK3 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.