Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 5/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13336281 | 0.90 | CDK2 (0.40) | AXLCDK2CCNA2TTKJAK3 | |
| SCHEMBL13336309 | 0.87 | CHEK1 (0.44) | GSK3BDYRK1ACLK2CLK3CDK2 | |
| SCHEMBL13336307 | 0.85 | PDK2 (0.42) | AXLGSK3BDYRK1ASYKCDK2 | |
| SCHEMBL13336128 | 0.83 | GSK3B (0.43) | AXLGSK3BDYRK1ASYKCLK2 | |
| SCHEMBL13336161 | 0.81 | MAP4K3 (0.42) | GSK3BDYRK1ACLK2CLK3CDK2 | |
| SCHEMBL13336284 | 0.80 | CDK2 (0.40) | CDK2CCNA2TTKJAK3JAK1 | |
| SCHEMBL13336175 | 0.79 | JAK1 (0.41) | CDK2CCNA2TTKJAK3JAK1 | |
| SCHEMBL13336122 | 0.78 | CHEK1 (0.47) | AXLGSK3BDYRK1ASYKJAK3 | |
| SCHEMBL13336280 | 0.77 | CDK2 (0.39) | CDK2CCNA2TTKJAK3JAK1 | |
| SCHEMBL13363267 | 0.76 | BRAF (0.54) | AXLSRCBRAFSYKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | AXL 4555/4885SRC 1021/4885BRAF 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.