Known targets — ChEMBL curated mechanism
COXFA4COXFA4L2GPD2MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3
The experimentally established mechanism targets of Metformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metformin SCHEMBL28854120 | 0.97 | HTT (0.37) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL1766280 | 0.97 | LMNA (0.36) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL8944 | 0.97 | — | — | |
| Metformin SCHEMBL18953625 | 0.94 | HTT (0.39) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL1560020 | 0.94 | LMNA (0.35) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL433864 | 0.94 | HTT (0.39) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL1290484 | 0.94 | LMNA (0.35) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL22127017 | 0.94 | LMNA (0.35) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL292820 | 0.94 | LMNA (0.35) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL4421557 | 0.94 | HTT (0.39) | LMNADPP4ADRA1AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115006376-B | Hydrogel spray and preparation method and application thereof | 南方科技大学 | 2023-11-24 | — | — | CN | claimed |
| CN-115006376-A | Hydrogel spray and preparation method and application thereof | 南方科技大学 | 2022-09-06 | — | — | CN | claimed |
| CN-115006376-B | Hydrogel spray and preparation method and application thereof | 南方科技大学 | 2023-11-24 | — | — | CN | disclosed |
| CN-115006376-B | Hydrogel spray and preparation method and application thereof | 南方科技大学 | 2023-11-24 | — | — | CN | disclosed |
| CN-115006376-A | Hydrogel spray and preparation method and application thereof | 南方科技大学 | 2022-09-06 | — | — | CN | disclosed |
| CN-115006376-A | Hydrogel spray and preparation method and application thereof | 南方科技大学 | 2022-09-06 | — | — | CN | disclosed |
| US-20150080433-A1 | METAL COORDINATED COMPOSITIONS | SYNTHONICS, INC. | 2015-03-19 | — | — | US | disclosed |
| US-20130184447-A1 | METAL COORDINATED COMPOSITIONS | SYNTHONICS, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-8389726-B2 | Metal coordinated compositions | SYNTHONICS, INC. (US) | 2013-03-05 | — | — | US | disclosed |
| US-20110275792-A1 | METAL COORDINATED COMPOSITIONS | SYNTHONICS, INC. | 2011-11-10 | — | — | US | disclosed |
| US-7989440-B2 | Metal coordinated compositions | SYNTHONICS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-7799937-B2 | Metal coordinated compositions | SYNTHONICS, INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-20090143338-A1 | Metal coordinated compositions | PICCARIELLO THOMAS | 2009-06-04 | — | — | US | disclosed |
| EP-1945191-A2 | METAL COORDINATED COMPOSITIONS | Synthonics, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| US-20080015352-A1 | Metal coordinated compositions | HTERT3, INC. | 2008-01-17 | — | — | US | disclosed |
| WO-2007050181-A2 | METAL COORDINATED COMPOSITIONS | SYNTHONICS, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| US-20060141054-A1 | Metal coordinated compositions | SYNTHONICS, INC. | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015352-A1 | Metal coordinated compositions | SLC30A6, SLC39A7, SLC39A14 | LMNA 4261/4885DPP4 1512/4885ADRA1A 3746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.