Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15209541 | 0.82 | ATM (0.50) | TSHRATMALDH1A1LMNAPOLB | |
| SCHEMBL15209538 | 0.82 | ATM (0.50) | TSHRATMALDH1A1LMNAPOLB | |
| SCHEMBL15215174 | 0.80 | ACHE (0.47) | TSHRATMALDH1A1LMNAPOLB | |
| SCHEMBL15211141 | 0.80 | ACHE (0.47) | TSHRATMALDH1A1LMNAPOLB | |
| SCHEMBL15215172 | 0.79 | ACHE (0.48) | TSHRATMALDH1A1LMNAPOLB | |
| SCHEMBL15215173 | 0.74 | ACHE (0.43) | TSHRATMALDH1A1LMNAPOLB | |
| SCHEMBL15215178 | 0.73 | TSHR (0.43) | TSHRATMALDH1A1LMNAPOLB | |
| SCHEMBL389034 | 0.70 | TSHR (0.55) | TSHRATMALDH1A1L3MBTL1ACHE | |
| SCHEMBL29563588 | 0.70 | MAPK1 (0.53) | TSHRATMALDH1A1LMNAACHE | |
| SCHEMBL20538250 | 0.70 | ALDH1A1 (0.66) | CTSLCTSSCTSKALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745650-B2 | alpha stereochemistry at the C-9 and C-10 OH positions offers excellent inhibition of cell growth against MDR sensitive cancer cell lines; starting materials are Paclitaxel and Docetaxel; increased biological activity; side effect reduction; solubility; better therapeutic profile; anticancer | TAPESTRY PHARMACEUTICALS, INC (US) | 2010-06-29 | — | — | US | disclosed |