Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15215173 | 0.86 | ACHE (0.43) | TSHRMEN1KMT2ATDP1ACHE | |
| SCHEMBL15210945 | 0.85 | TDP1 (0.44) | TSHRMEN1KMT2ATDP1ACHE | |
| SCHEMBL15209985 | 0.85 | TDP1 (0.44) | TSHRMEN1KMT2ATDP1ACHE | |
| SCHEMBL15209541 | 0.80 | ATM (0.50) | TSHRTDP1ACHEATMALDH1A1 | |
| SCHEMBL15209538 | 0.80 | ATM (0.50) | TSHRTDP1ACHEATMALDH1A1 | |
| SCHEMBL15215172 | 0.79 | ACHE (0.48) | TSHRMEN1KMT2ATDP1ACHE | |
| SCHEMBL15215174 | 0.78 | ACHE (0.47) | TSHRMEN1KMT2ATDP1ACHE | |
| SCHEMBL15211141 | 0.78 | ACHE (0.47) | TSHRMEN1KMT2ATDP1ACHE | |
| SCHEMBL13342957 | 0.73 | CTSL (0.44) | TSHRTDP1ACHEATMALDH1A1 | |
| SCHEMBL389034 | 0.73 | TSHR (0.55) | TSHRMEN1KMT2ATDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458177-B2 | Oxazolidin-2-one compounds and uses thereof | NOVARTIS AG (CH) | 2016-10-04 | — | — | US | disclosed |
| US-9458177-B2 | Oxazolidin-2-one compounds and uses thereof | NOVARTIS AG (CH) | 2016-10-04 | — | — | US | disclosed |
| US-20140378450-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2014-12-25 | — | — | US | disclosed |
| US-20140378450-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2014-12-25 | — | — | US | disclosed |
| US-8865894-B2 | Oxazolidin-2-one compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-8865894-B2 | Oxazolidin-2-one compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130225574-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2013-08-29 | — | — | US | disclosed |
| US-20130225574-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378450-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | TSHR 3875/4885MEN1 4186/4885KMT2A 3372/4885 |
| US-20130225574-A1 | OXAZOLIDIN-2-ONE COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | TSHR 3875/4885MEN1 4186/4885KMT2A 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.