Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954358 | 0.87 | CA1 (0.52) | CA1CA2CA12CA7CA9 | |
| SCHEMBL18573170 | 0.87 | POLB (0.53) | CA1CA2CA12CA7CA9 | |
| SCHEMBL16952030 | 0.84 | CTSL (0.41) | POLBKDM4EGAALMNACTSL | |
| SCHEMBL1188442 | 0.84 | NOTUM (0.57) | NOTUMCA1CA2CA12CA7 | |
| SCHEMBL16533898 | 0.82 | CA1 (0.50) | CA1CA2CA12CA7CA9 | |
| SCHEMBL3453107 | 0.81 | LMNA (0.50) | CA12CA9POLBKDM4EGAA | |
| Methyl 3,5-Dibromobenzoate SCHEMBL2408987 | 0.81 | NOTUM (0.67) | NOTUMCA1CA2CA12CA7 | |
| SCHEMBL14710190 | 0.81 | LMNA (0.46) | CA12CA9POLBKDM4EGAA | |
| SCHEMBL184614 | 0.81 | NOTUM (0.67) | NOTUMCA1CA2CA12CA7 | |
| SCHEMBL14107665 | 0.81 | MEN1 (0.49) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709492-B2 | Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2010-05-04 | — | — | US | disclosed |