Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.57 |
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.57 |
| ▸ | HTR3B | O95264 | 4/20 | 0.57 |
| ▸ | HTR3A | P46098 | 4/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6264215 | 0.83 | ADRB1 (0.62) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL23057208 | 0.82 | MEN1 (0.52) | CYP1A2CYP3A4CYP2C19ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6528621 | 0.80 | HTR6 (0.58) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL27112881 | 0.80 | ADRB1 (0.54) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL1383637 | 0.80 | GAA (0.56) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL27114834 | 0.80 | HTR6 (0.51) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL19623431 | 0.79 | HDAC1 (0.56) | CYP1A2HTTALDH1A1MAPTHDAC4 | |
| SCHEMBL21965859 | 0.79 | ADRB1 (0.57) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL25492981 | 0.79 | ADRB1 (0.57) | HTR7HTR1AADRB1HTR3EHTR3B | |
| SCHEMBL5749961 | 0.79 | HTR7 (0.57) | HTR7HTR1AADRB1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |