Sugi Predict

Sugi Predict / Compounds / SCHEMBL133465

SCHEMBL133465

SCHEMBL133465

CN(C)c1ccccc1/N=N/c1ccccc1[C]=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.37
▸ GAA P10253 4/20 0.37
▸ ALDH1A1 P00352 4/20 0.37
▸ SMN1; SMN2 Q16637 3/20 0.37
▸ TP53 P04637 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ KDM4E B2RXH2 3/20 0.36
▸ MEN1 O00255 4/20 0.36
▸ KMT2A Q03164 4/20 0.36
▸ NPC1 O15118 3/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ ALPL P05186 1/20 0.34
▸ ALPI P09923 1/20 0.34
▸ ALPG P10696 1/20 0.34
▸ MYC P01106 1/20 0.34
▸ MAPK1 P28482 2/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ POLB P06746 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8722208 0.84 MAPT (0.48) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL1025289 0.82 SMN1; SMN2 (0.42) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL1025290 0.82 SMN1; SMN2 (0.42) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL97296 0.80 ALDH1A1 (0.45) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL4252084 0.77 KMT2A (0.45) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL4252088 0.77 KMT2A (0.45) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL157008 0.77 NPC1 (0.61) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL157009 0.77 NPC1 (0.61) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL7787560 0.76 KMT2A (0.44) MAPTGAAALDH1A1SMN1; SMN2TP53
SCHEMBL7787561 0.76 KMT2A (0.44) MAPTGAAALDH1A1SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0137539-B1 N-SUBSTITUTED TETRAHYDROTHIAZINES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS PESTICIDES SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1988-05-04 — — EP claimed
US-20190337988-A1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES XIGEN INFLAMMATION LTD. (CY) 2019-11-07 — — US disclosed
US-10023615-B2 Efficient transport into white blood cells XIGEN INFLAMMATION LTD. (CY) 2018-07-17 — — US disclosed
CN-102256998-B Novel transporter constructs and transporter cargo binding molecules 希根因弗兰曼斯有限公司 2018-06-15 — — CN disclosed
EP-2361260-B1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES XIGEN INFLAMMATION LTD (CY) 2016-08-17 — — EP disclosed
CN-102256999-B Efficient transport to leukocytes XIGEN INFLAMMATION LTD. (CY) 2016-03-02 — — CN disclosed
EP-2947093-A1 EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS Xigen Inflammation Ltd. (CY) 2015-11-25 — — EP disclosed
EP-2361259-B1 EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS XIGEN INFLAMMATION LTD (CY) 2015-04-22 — — EP disclosed
US-20120142584-A1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES XIGEN, S.A. (CH) 2012-06-07 — — US disclosed
US-20120058137-A1 EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS XIGEN, S.A. (CH) 2012-03-08 — — US disclosed
CN-102256999-A Efficient transport to leukocytes XIGEN SA 2011-11-23 — — CN disclosed
CN-102256998-A Novel transporter constructs and transporter cargo binding molecules XIGEN SA 2011-11-23 — — CN disclosed
EP-2361260-A1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES Xigen S.A. (CH) 2011-08-31 — — EP disclosed
EP-2361259-A1 EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS Xigen S.A. (CH) 2011-08-31 — — EP disclosed
WO-2010072405-A1 EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS XIGEN S.A. (CH) 2010-07-01 — — WO disclosed
WO-2010072406-A1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES XIGEN S.A. (CH) 2010-07-01 — — WO disclosed
WO-2010072228-A1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES XIGEN S.A. (CH) 2010-07-01 — — WO disclosed
WO-2010072275-A1 EFFICIENT DELIVERY OF MEDICAMENTS INTO WHITE BLOOD CELLS XIGEN S.A. (CH) 2010-07-01 — — WO disclosed
EP-0137539-B1 N-SUBSTITUTED TETRAHYDROTHIAZINES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS PESTICIDES SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1988-05-04 — — EP disclosed
EP-0137539-A1 N-substituted tetrahydrothiazines, process for their preparation, and their use as pesticides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1985-04-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058137-A1 EFFICIENT TRANSPORT INTO WHITE BLOOD CELLS SLC2A1, SLC2A3, SLC2A2 MAPT 2065/4885GAA 225/4885ALDH1A1 848/4885
US-20190337988-A1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES SLC43A1, SLCO2B1, SLC29A1 MAPT 985/4885GAA 274/4885ALDH1A1 1050/4885
US-20120142584-A1 NOVEL TRANSPORTER CONSTRUCTS AND TRANSPORTER CARGO CONJUGATE MOLECULES SLC43A1, SLCO2B1, SLC29A1 MAPT 985/4885GAA 274/4885ALDH1A1 1050/4885
US-10023615-B2 Efficient transport into white blood cells SLC2A1, SLC2A3, SLC2A2 MAPT 2065/4885GAA 225/4885ALDH1A1 848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.