Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12056089 | 0.84 | POLB (0.47) | LMNAPOLBTDP1APEX1HTT | |
| SCHEMBL12056091 | 0.83 | POLB (0.46) | POLBTDP1APEX1HTTMEN1 | |
| SCHEMBL10005504 | 0.83 | IDO1 (0.46) | IDO1NPSR1SMN1; SMN2LMNAPOLB | |
| SCHEMBL23391659 | 0.81 | IDO1 (0.45) | IDO1NPSR1SMN1; SMN2LMNAPOLB | |
| SCHEMBL15120385 | 0.79 | NAAA (0.49) | NPSR1TDP1 | |
| SCHEMBL20559023 | 0.79 | POLB (0.42) | POLBTDP1APEX1HTTALDH1A1 | |
| SCHEMBL2847525 | 0.78 | ELANE (0.49) | NPSR1SMN1; SMN2LMNATDP1CYP1A2 | |
| SCHEMBL23943448 | 0.78 | NPSR1 (0.48) | IDO1NPSR1SMN1; SMN2LMNAPOLB | |
| SCHEMBL13854684 | 0.77 | POLB (0.43) | SMN1; SMN2POLBTDP1APEX1HTT | |
| SCHEMBL262736 | 0.77 | TDP1 (0.47) | IDO1TDP1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3598181-B1 | VINYLIC MONOMER AND PREPOLYMER COMPRISING SAME | ALCON INC (CH) | 2021-06-23 | — | — | EP | disclosed |
| US-20130172504-A1 | SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS | NOVARTIS AG (CH) | 2013-07-04 | — | — | US | disclosed |
| US-20130172504-A1 | SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS | NOVARTIS AG (CH) | 2013-07-04 | — | — | US | disclosed |
| US-8404759-B2 | soft contact lens has a hydrophilic surface without post-curing surface treatment; macromolecular monomer of oligosiloxane mono-endcapped with (meth)acrylate or (meth)acrylamide, that copolymerizes with hydrophilic monomer and a vinylic ketone monomer | NOVARTIS AG (CH) | 2013-03-26 | — | — | US | disclosed |
| US-8404759-B2 | soft contact lens has a hydrophilic surface without post-curing surface treatment; macromolecular monomer of oligosiloxane mono-endcapped with (meth)acrylate or (meth)acrylamide, that copolymerizes with hydrophilic monomer and a vinylic ketone monomer | NOVARTIS AG (CH) | 2013-03-26 | — | — | US | disclosed |
| WO-2010056687-A2 | SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS | NOVARTIS AG (CH) | 2010-05-20 | — | — | WO | disclosed |
| US-20100120939-A1 | SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS | ALCON INC. (CH) | 2010-05-13 | — | — | US | disclosed |
| US-20100120939-A1 | SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS | ALCON INC. (CH) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120939-A1 | SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS | CRYAA, CRYAB, PCNA | IDO1 4291/4885NPSR1 4492/4885SMN1; SMN2 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.