Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP9X | Q93008 | 11/20 | 0.78 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.78 |
| ▸ | USP5 | P45974 | 1/20 | 0.78 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | USP24 | Q9UPU5 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289031 | 0.92 | USP9X (0.66) | USP9XUCHL1USP5STAT3ALDH1A1 | |
| SCHEMBL864117 | 0.88 | USP9X (0.78) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL864169 | 0.88 | USP9X (0.78) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL882501 | 0.88 | USP9X (1.00) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL1317671 | 0.88 | USP9X (1.00) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL1317674 | 0.88 | USP9X (1.00) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL1317669 | 0.88 | USP9X (1.00) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL864170 | 0.88 | USP9X (0.78) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL864115 | 0.88 | USP9X (0.78) | USP9XUCHL1USP5STAT3USP24 | |
| SCHEMBL864116 | 0.88 | USP9X (0.78) | USP9XUCHL1USP5STAT3USP24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745468-B2 | tyrphostin-like compounds that display a significant potency as kinase inhibitors, cause the downregulation of c-myc proto-oncogene and inhibit the growth and survival of cancerous cell lines; antiproliferative agents | Board of Regents, University of Texas Systems The (US) | 2010-06-29 | — | — | US | disclosed |
| WO-2008005954-A2 | TRYPHOSTIN-ANALOGS FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-01-10 | — | — | WO | disclosed |