SCHEMBL1334951

SCHEMBL1334951

CCc1c(N)c(C)cc(CS)c1N

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.37
NOS2 P35228 2/20 0.37
ALDH1A1 P00352 5/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
TP53 P04637 1/20 0.34
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CYP1A2 P05177 1/20 0.33
ALOX15 P16050 1/20 0.33
CASP7 P55210 1/20 0.33
HIF1A Q16665 1/20 0.33
HSD17B10 Q99714 1/20 0.33
NOS1 P29475 1/20 0.33
KDM4E B2RXH2 1/20 0.32
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL261835 0.88 ALDH1A1 (0.37) ALDH1A1MAPTHTTTP53CYP3A4
SCHEMBL1334970 0.87 POLB (0.33) NOS3NOS2MAPTHTTTDP1
SCHEMBL42756 0.85 ALDH1A1 (0.46) NOS3NOS2ALDH1A1MAPTHTT
SCHEMBL29430615 0.85 ALDH1A1 (0.46) NOS3NOS2ALDH1A1MAPTHTT
SCHEMBL1334762 0.84 ALDH1A1 (0.42) NOS3NOS2ALDH1A1MAPTHTT
SCHEMBL9712137 0.83 ALDH1A1 (0.44) NOS3NOS2ALDH1A1MAPTHTT
Ammonia Solution, Strong SCHEMBL4989525 0.83 ALDH1A1 (0.44) NOS3NOS2ALDH1A1MAPTHTT
SCHEMBL1334752 0.83 HTT (0.39) NOS3NOS2ALDH1A1MAPTHTT
SCHEMBL342202 0.80 ALDH1A1 (0.46) NOS3NOS2ALDH1A1MAPTHTT
SCHEMBL5141175 0.78 ALDH1A1 (0.45) NOS3NOS2ALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3521909-A1 METHOD FOR MANUFACTURING SPECTACLE LENS, AND SPECTACLE LENS Hoya Lens Thailand Ltd. (TH) 2019-08-07 EP disclosed
US-20180372915-A1 METHOD FOR MANUFACTURING SPECTACLE LENS, AND SPECTACLE LENS HOYA LENS THAILAND LTD. (TH) 2018-12-27 US disclosed
EP-1504869-B1 PROCESS FOR PRODUCING OPTICAL MEMBER, PROCESS FOR PRODUCING PLASTIC LENS, GASKET FOR PLASTIC LENS MOLDING, AND JIG FOR MONOMER INJECTION HOYA CORP (JP) 2018-03-28 EP disclosed
EP-2351638-B1 PLASTIC LENS MANUFACTURING METHOD AND MANUFACTURING DEVICE HOYA CORP (JP) 2016-11-23 EP disclosed
EP-2090602-B1 Transparent molded objects, optical member, plastic lens, and processes for producing these HOYA CORP (JP) 2016-03-16 EP disclosed
EP-1759824-B1 METHOD OF MANUFACTURING PLASTIC LENSES HOYA CORP (JP) 2016-03-09 EP disclosed
US-20150259509-A1 TRANSPARENT MOLDED ARTICLE, OPTICAL MEMBER, PLASTIC LENS, AND METHODS OF MANUFACTURING SAME HOYA CORPORATION (JP) 2015-09-17 US disclosed
CN-101648421-B Method of manufacturing plastic lens, gasket for molding plastic lens, casting mold for molding plastic lens, casting jig for plastic lens starting material liquid, holding member for plastic lens cas HOYA CORPORATION (JP) 2014-10-15 CN disclosed
US-8377345-B2 Method of manufacturing optical member, method of manufacturing plastic lens, gasket for molding plastic lens, and jog for casting monomer HOYA CORPORATION (JP) 2013-02-19 US disclosed
US-8372317-B2 Method of casting plastic lens starting material liquid and casting apparatus and method of manufacturing plastic lens HOYA CORPORATION (JP) 2013-02-12 US disclosed
EP-1384736-B1 TRANSPARENT MOLDED OBJECTS, OPTICAL MEMBER, PLASTIC LENS, AND PROCESSES FOR PRODUCING THESE HOYA CORP (JP) 2009-08-12 EP disclosed
US-20080029914-A1 Method of manufacturing plastic lens, gasket for molding plastic lens, casting mold for molding plastic lens, casting jig for plastic lens starting material liquid, holding member for plastic lens casting mold, and plastic lens manufacturing apparatus HOYA CORPORATION (JP) 2008-02-07 US disclosed
US-20080018005-A1 Method Of Manufacturing Plastic Lens, Gasket For Molding Plastic Lens, Casting Mold For Molding Plastic Lens, Casting Jig For Plastic Lens Starting Material Liquid, Holding Member For Plastic Lens Casting Mold, And Plastic Lens Manufacturing Apparatus HOYA CORPORATION 2008-01-24 US disclosed
EP-1759824-A1 PROCESSES FOR PRODUCTION OF PLASTIC LENSES, GASKET FOR MOLDING PLASTIC LENSES, MOLDS FOR MOLDING PLASTIC LENSES, INJECTION JIG FOR THE RAW MATERIAL FLUID OF PLASTIC LENSES, HOLDING FIXTURE FOR THE MOLDS FOR PLASTIC LENSES, AND PRODUCTION UNIT FOR PLASTIC LENSES HOYA CORPORATION (JP) 2007-03-07 EP disclosed
US-20060155093-A1 Polyol compound, transparent molded article and method of manufacturing transparent molded article HOYA CORPORATION (JP) 2006-07-13 US disclosed
EP-1640394-A1 POLYOL COMPOUND, TRANSPARENT MOLDED OBJECTS, AND PROCESS FOR PRODUCING TRANSPARENT MOLDED OBJECT HOYA CORPORATION (JP) 2006-03-29 EP disclosed
US-20050200033-A1 Process for producing optical member, process for producing plastic lens, gasket for plastic lens molding, and jig for monomer injection HOYA CORPORATION (JP) 2005-09-15 US disclosed
EP-1504869-A1 PROCESS FOR PRODUCING OPTICAL MEMBER, PROCESS FOR PRODUCING PLASTIC LENS, GASKET FOR PLASTIC LENS MOLDING, AND JIG FOR MONOMER INJECTION HOYA CORPORATION (JP) 2005-02-09 EP disclosed
US-20040151915-A1 Transparent molded objects, optical member, plastic lens, and processes for producing these HOYA CORPORATION (JP) 2004-08-05 US disclosed
EP-1384736-A1 TRANSPARENT MOLDED OBJECTS, OPTICAL MEMBER, PLASTIC LENS, AND PROCESSES FOR PRODUCING THESE HOYA CORPORATION (JP) 2004-01-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180372915-A1 METHOD FOR MANUFACTURING SPECTACLE LENS, AND SPECTACLE LENS IDO1, IDO2, KYNU NOS3 1262/4885NOS2 833/4885ALDH1A1 1375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.