Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PPM1B | O75688 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170891 | 0.88 | ALDH1A1 (0.38) | TDP1KMT2A | |
| SCHEMBL9794612 | 0.79 | TDP1 (0.48) | TDP1EGLN1MEN1NPC1KMT2A | |
| SCHEMBL19323989 | 0.79 | TDP1 (0.48) | TDP1EGLN1MEN1NPC1KMT2A | |
| SCHEMBL13342009 | 0.75 | ALDH1A1 (0.33) | KMT2APPM1BPTPN1PPP1CC | |
| SCHEMBL13341771 | 0.75 | ALDH1A1 (0.33) | KMT2APPM1BPTPN1PPP1CC | |
| SCHEMBL12062469 | 0.75 | CYP3A4 (0.37) | PPM1BPTPN1PPP1CC | |
| SCHEMBL6251850 | 0.72 | MGAM (0.44) | TDP1EGLN1MEN1NPC1KMT2A | |
| SCHEMBL14079889 | 0.71 | ALDH1A1 (0.36) | TDP1KMT2A | |
| SCHEMBL7672142 | 0.70 | TDP1 (0.42) | TDP1EGLN1MEN1NPC1KMT2A | |
| SCHEMBL28088679 | 0.70 | TDP1 (0.42) | TDP1EGLN1MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121674-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING A MACROCYCLIC PROTEASE INHIBITOR OF HCV | TIBOTEC PHARM LTD (IE) | 2010-05-12 | — | — | EP | disclosed |