Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13320597 | 0.85 | ALDH1A1 (0.57) | NPC1RAB9ALMNATOP2AALDH1A1 | |
| SCHEMBL6085448 | 0.85 | SMN1; SMN2 (0.54) | P2RX7L3MBTL1PKMALDH1A1CNR2 | |
| SCHEMBL3323990 | 0.84 | MEN1 (0.51) | RAB9ALMNATOP2AP2RX5P2RX4 | |
| SCHEMBL3323184 | 0.77 | RAB9A (0.51) | RAB9ALMNAL3MBTL1ALDH1A1CNR2 | |
| SCHEMBL5275178 | 0.75 | POLB (0.64) | NPC1RAB9ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL16272296 | 0.74 | HSP90AA1 (0.43) | LMNATOP2AL3MBTL1ALDH1A1HSP90AA1 | |
| SCHEMBL18715373 | 0.74 | NPC1 (0.60) | NPC1RAB9ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL12180472 | 0.74 | ACHE (0.60) | NPC1RAB9ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL30697348 | 0.73 | CTNNB1 (0.66) | NPC1RAB9AL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL29115858 | 0.73 | CTNNB1 (0.66) | NPC1RAB9AL3MBTL1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130497-A1 | Therapeutic Compounds | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130497-A1 | Therapeutic Compounds | NFATC1, NAT1, AADAC | NPC1 1318/4885RAB9A 1186/4885LMNA 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.