Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12655740 | 0.87 | KDM4E (0.70) | POLBHPGDKDM4EHTTGRM3 | |
| SCHEMBL12655726 | 0.81 | L3MBTL1 (0.60) | POLBHPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL12626097 | 0.80 | KDM4E (0.61) | POLBHPGDKDM4EHTTGRM3 | |
| SCHEMBL17966169 | 0.80 | POLB (0.72) | POLBHPGDGRM3USP2CYP3A4 | |
| SCHEMBL12626102 | 0.77 | POLB (0.68) | POLBHPGDGRM3USP2CYP3A4 | |
| SCHEMBL20631562 | 0.77 | HPGD (0.86) | POLBHPGDKDM4EHTTALDH1A1 | |
| SCHEMBL9792247 | 0.76 | HPGD (0.79) | POLBHPGDKDM4EHTTSMN1; SMN2 | |
| SCHEMBL12626093 | 0.76 | L3MBTL1 (0.54) | POLBHPGDHTTUSP2SMN1; SMN2 | |
| SCHEMBL25495296 | 0.76 | L3MBTL1 (0.54) | POLBKDM4EHTTSMN1; SMN2 | |
| SCHEMBL10053023 | 0.74 | HPGD (0.75) | POLBHPGDALDH1A1TSHRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010051476-A1 | FILAMIN A-BINDING ANTI-INFLAMMATORY ANALGESIC | PAIN THERAPEUTICS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |