Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367730 | 0.87 | LMNA (0.37) | SMN1; SMN2LMNAKMT2ACYP11B1CYP11B2 | |
| SCHEMBL13354598 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAKMT2AKDM4ETOP2A | |
| SCHEMBL12146392 | 0.74 | CCR4 (0.35) | SMN1; SMN2LMNATMPRSS15 | |
| SCHEMBL34474068 | 0.72 | KDM4E (0.32) | SMN1; SMN2KMT2AKDM4EHPGDALDH1A1 | |
| SCHEMBL481978 | 0.72 | PPARG (0.39) | SMN1; SMN2LMNAKMT2AKDM4ETSHR | |
| SCHEMBL12146610 | 0.71 | LMNA (0.45) | LMNAKMT2AHPGDALDH1A1MAPT | |
| SCHEMBL12146484 | 0.71 | VNN1 (0.46) | KMT2AKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL16186772 | 0.70 | CCR4 (0.34) | PGK1TSHR | |
| SCHEMBL15509174 | 0.69 | HPGD (0.40) | SMN1; SMN2KDM4ETLR7HPGDALDH1A1 | |
| SCHEMBL18697440 | 0.68 | ELANE (0.40) | LMNAKDM4ETSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056311-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |