Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.32 |
| ▸ | PLAU | P00749 | 2/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CCR4 | P51679 | 2/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | PRKACG | P22612 | 1/20 | 0.32 |
| ▸ | PRKACB | P22694 | 1/20 | 0.32 |
| ▸ | PRKCH | P24723 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13354594 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNATMPRSS15KDM4EKMT2A | |
| SCHEMBL1367730 | 0.70 | LMNA (0.37) | SMN1; SMN2LMNATMPRSS15KMT2APGK1 | |
| SCHEMBL20844402 | 0.67 | JAK3 (0.43) | — | |
| SCHEMBL12146484 | 0.66 | VNN1 (0.46) | KDM4EKMT2AALDH1A1 | |
| SCHEMBL15509174 | 0.65 | HPGD (0.40) | SMN1; SMN2KDM4ETLR7PLAUALDH1A1 | |
| SCHEMBL12146610 | 0.64 | LMNA (0.45) | LMNAKMT2AALDH1A1 | |
| SCHEMBL14241563 | 0.63 | SYK (0.44) | SMN1; SMN2LMNAKDM4EKMT2APGK1 | |
| SCHEMBL9013550 | 0.62 | NPC1 (0.50) | SMN1; SMN2LMNAKDM4EKMT2ATOP2A | |
| SCHEMBL28310632 | 0.61 | STK17A (0.40) | PRKD3PRKCIPRKD1 | |
| SCHEMBL21865595 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056311-A1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |