Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711459 | 0.85 | TP53 (0.49) | HTR6TP53THRBRXFP1POLB | |
| SCHEMBL13356746 | 0.78 | SLC6A2 (0.46) | HTR6TP53POLBPLA2G2AMAPT | |
| SCHEMBL711445 | 0.71 | PLA2G2A (0.44) | THRBPOLBPLA2G2AP2RX7 | |
| SCHEMBL709821 | 0.69 | CHRM1 (0.46) | TP53SMN1; SMN2PLA2G2A | |
| SCHEMBL711222 | 0.69 | P2RX7 (0.38) | HTR6TP53POLBSMN1; SMN2PLA2G2A | |
| SCHEMBL711475 | 0.69 | PLA2G2A (0.39) | HTR6TP53POLBSMN1; SMN2PLA2G2A | |
| SCHEMBL710383 | 0.69 | CNR1 (0.45) | TP53POLBPLA2G2AP2RX7 | |
| SCHEMBL711655 | 0.69 | TP53 (0.38) | TP53POLBSMN1; SMN2PLA2G2AP2RX7 | |
| SCHEMBL709121 | 0.68 | P2RX7 (0.44) | HTR6TP53SMN1; SMN2PLA2G2AMAPT | |
| SCHEMBL4073048 | 0.68 | HTR6 (0.46) | HTR6TP53THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |