Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13357574 | 0.77 | ROCK1 (0.66) | ROCK1ROCK2CLK1MEN1MAPT | |
| SCHEMBL13357606 | 0.76 | ROCK1 (0.70) | ROCK1ROCK2MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL13357581 | 0.74 | ROCK1 (0.60) | ROCK1ROCK2MEN1KMT2AGSTO1 | |
| SCHEMBL13357633 | 0.74 | ROCK1 (0.65) | ROCK1ROCK2CLK1RAB9AMEN1 | |
| SCHEMBL1883429 | 0.73 | PARP1 (0.74) | ROCK1ROCK2RAB9AMEN1MAPT | |
| SCHEMBL13357607 | 0.73 | ROCK2 (0.70) | ROCK1ROCK2MEN1MAPTKMT2A | |
| SCHEMBL12248876 | 0.72 | PARP1 (0.76) | ROCK1ROCK2RAB9AMEN1MAPT | |
| SCHEMBL10699534 | 0.72 | ABL1 (0.73) | ROCK1ROCK2RAB9AMEN1MAPT | |
| SCHEMBL1884815 | 0.72 | MAPT (0.73) | ROCK1ROCK2CLK1RAB9AMEN1 | |
| SCHEMBL12281965 | 0.70 | ROCK1 (0.63) | ROCK1ROCK2CLK1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558607-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |