Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966860 | 0.73 | FAAH (0.70) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL5296255 | 0.73 | FAAH (0.70) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL5966857 | 0.73 | FAAH (0.70) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL20170448 | 0.73 | MAPT (0.43) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL16658608 | 0.72 | FAAH (0.55) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL28142208 | 0.71 | FAAH (0.59) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL6610344 | 0.70 | FAAH (0.83) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL1176906 | 0.70 | FAAH (0.69) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL28045523 | 0.69 | FAAH (0.47) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL10316675 | 0.69 | FAAH (0.67) | FAAHMEN1MAPK1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558607-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |