Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257780 | 0.87 | LYN (0.56) | ALDH1A1SMN1; SMN2MEN1AGTR1HTT | |
| SCHEMBL13359156 | 0.82 | MAPK14 (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ALYN | |
| SCHEMBL13359211 | 0.80 | MAPK14 (0.40) | ALDH1A1MEN1HTTKMT2ALYN | |
| SCHEMBL13359241 | 0.79 | LYN (0.55) | MEN1KMT2ALYNMAPK9POLB | |
| SCHEMBL13359264 | 0.78 | LYN (0.59) | ALDH1A1SMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL13359212 | 0.77 | LYN (0.51) | ALDH1A1SMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL14301265 | 0.74 | ABCG2 (0.41) | MAPK14 | |
| SCHEMBL3257628 | 0.73 | LYN (0.72) | ALDH1A1SMN1; SMN2HTTKMT2ALYN | |
| SCHEMBL3254683 | 0.72 | MAPK14 (0.63) | SMN1; SMN2KMT2ALYNMAPK9TSHR | |
| SCHEMBL13798001 | 0.71 | MAPK14 (0.60) | LYNMAPK9MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |