Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 4/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | DHPS | P49366 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359264 | 0.87 | LYN (0.59) | LYNMAPK9MAPK14CYP1A2CYP2C9 | |
| SCHEMBL13359212 | 0.86 | LYN (0.51) | LYNMAPK9MAPK14MEN1KMT2A | |
| SCHEMBL13797958 | 0.86 | LYN (0.72) | LYNMAPK9MAPK14BRAF | |
| SCHEMBL13359286 | 0.81 | MAPK14 (0.49) | LYNMAPK9MAPK14CYP1A2CYP3A4 | |
| SCHEMBL13359141 | 0.80 | LYN (0.45) | LYNMAPK9MAPK14MEN1KMT2A | |
| SCHEMBL13359163 | 0.79 | ALDH1A1 (0.42) | LYNMAPK9MAPK14MEN1HPGD | |
| SCHEMBL3257628 | 0.78 | LYN (0.72) | LYNMAPK9MAPK14KMT2ABRAF | |
| SCHEMBL13797956 | 0.77 | LYN (0.69) | LYNMAPK9MAPK14CYP1A2CYP3A4 | |
| SCHEMBL13797967 | 0.77 | LYN (0.69) | LYNMAPK9MAPK14CYP1A2CYP3A4 | |
| SCHEMBL13797953 | 0.77 | LYN (0.71) | LYNMAPK9MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |