Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | LDLR | P01130 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359226 | 0.88 | MAPK1 (0.55) | HTTLMNALYNMAPK9KDM4E | |
| SCHEMBL13359216 | 0.88 | MEN1 (0.56) | HTTLMNAL3MBTL1CSF1RBRAF | |
| SCHEMBL3255235 | 0.82 | HPGD (0.56) | HTTLMNAL3MBTL1KDM4EMEN1 | |
| SCHEMBL13797972 | 0.81 | DHPS (0.47) | HTTLMNAL3MBTL1LYNMAPK9 | |
| SCHEMBL13359208 | 0.81 | MAPK1 (0.53) | HTTCSF1RBRAFKDM4EMEN1 | |
| SCHEMBL3255596 | 0.81 | HTT (0.57) | HTTLMNAL3MBTL1KDM4EMEN1 | |
| SCHEMBL3257628 | 0.80 | LYN (0.72) | HTTBRAFLYNMAPK9ALDH1A1 | |
| SCHEMBL13359290 | 0.79 | DHPS (0.44) | HTTL3MBTL1LYNMAPK9KDM4E | |
| SCHEMBL13811161 | 0.77 | DHPS (0.43) | HTTLMNAL3MBTL1LYNMAPK9 | |
| SCHEMBL13359217 | 0.76 | MAPT (0.47) | HTTLYNMAPK9KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |