Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797972 | 0.90 | DHPS (0.47) | DHPSHPGDHTTCHRNA7PPARG | |
| SCHEMBL13811161 | 0.84 | DHPS (0.43) | DHPSHPGDHTTCHRNA7PPARG | |
| SCHEMBL13359291 | 0.83 | SMN1; SMN2 (0.51) | DHPSHPGDHTTNPC1RAB9A | |
| SCHEMBL13359266 | 0.81 | MAPK14 (0.59) | DHPSHPGDHTTPPARGMAPK14 | |
| SCHEMBL13797975 | 0.80 | MAPK14 (0.55) | HPGDHTTPPARGMAPK14RAB9A | |
| SCHEMBL13359225 | 0.79 | HTT (0.52) | HPGDHTTNPC1RAB9AKDM4E | |
| SCHEMBL4001894 | 0.77 | MAPK14 (0.73) | MAPK14LYNMAPK9ALDH1A1 | |
| SCHEMBL13359167 | 0.75 | MAPK14 (0.54) | HPGDHTTPPARGMAPK14HDAC2 | |
| SCHEMBL3258140 | 0.72 | ALDH1A1 (0.54) | HPGDCHRNA7HDAC2HDAC3HDAC4 | |
| SCHEMBL6284802 | 0.71 | LMNA (0.51) | HPGDHTTCHRNA7HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |