Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982049 | 0.72 | ALDH1A1 (0.39) | ALDH1A1CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL15828700 | 0.70 | KIF11 (0.51) | PPARGALDH1A1MAPK14HPGDHTT | |
| SCHEMBL21568082 | 0.70 | HTT (0.51) | PPARGALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL15562919 | 0.69 | ALDH1A1 (0.39) | ALDH1A1CYP2C9CYP2C19MAPTNPSR1 | |
| SCHEMBL13849156 | 0.68 | ALDH1A1 (0.52) | PPARGALDH1A1MEN1CYP2C9KMT2A | |
| SCHEMBL20436796 | 0.67 | PPARG (0.63) | PPARGALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL21264082 | 0.67 | BTK (0.46) | PPARGMEN1KMT2AHPGDHTT | |
| SCHEMBL5732332 | 0.67 | HPGD (0.46) | PPARGALDH1A1CYP2C19HPGDHTT | |
| SCHEMBL10443672 | 0.66 | HSD17B10 (0.39) | MEN1CYP2D6KMT2ACYP2C19HTT | |
| SCHEMBL7599608 | 0.65 | MAPT (0.54) | ALDH1A1MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |