Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133383 | 0.77 | ATM (0.46) | ATMPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5526295 | 0.75 | BRD4 (0.45) | ATMPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10422710 | 0.75 | NPSR1 (0.35) | ATMPOLBALDH1A1KDM4EMEN1 | |
| SCHEMBL14838847 | 0.72 | ATM (0.40) | ATMPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4759633 | 0.71 | POLB (0.43) | ATMPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18921179 | 0.71 | OPRM1 (0.46) | ATMPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27265842 | 0.70 | ATM (0.41) | ATMPOLBSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3147434 | 0.70 | POLB (0.46) | ATMPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL136687 | 0.69 | ATM (0.44) | ATMPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4857506 | 0.68 | ALDH1A1 (0.42) | ATMPOLBALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232275-B2 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and -pyrimidines as antiviral agents | WAYNE STATE UNIVERSITY (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110275652-A1 | 2,2-BIS-(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL-PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | WAYNE STATE UNIVERSITY | 2011-11-10 | — | — | US | disclosed |
| EP-1490368-B1 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV WAYNE STATE (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20090118308-A1 | 2,2-Bis-(hydroxymethyl)cyclopropylidenemethyl-Purines and -Pyrimidines As Antiviral Agents | WAYNE STATE UNIVERSITY (US) | 2009-05-07 | — | — | US | disclosed |
| US-7393855-B2 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrimidines as antiviral agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1490368-A4 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | UNIV WAYNE STATE (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20050113393-A1 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrmindines as antiviral agents | WAYNE STATE UNIVERSITY (US) | 2005-05-26 | — | — | US | disclosed |
| EP-1490368-A2 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | Wayne State University (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003104440-A2 | 2,2-BIS(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL - PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | WAYNE STATE UNIVERSITY (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275652-A1 | 2,2-BIS-(HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL-PURINES AND -PYRIMIDINES AS ANTIVIRAL AGENTS | TPMT, HPRT1, MTAP | ATM 4606/4885POLB 363/4885SMN1; SMN2 1963/4885 |
| US-20050113393-A1 | 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and pyrmindines as antiviral agents | TPMT, HPRT1, MTAP | ATM 4632/4885POLB 388/4885SMN1; SMN2 1945/4885 |
| US-20090118308-A1 | 2,2-Bis-(hydroxymethyl)cyclopropylidenemethyl-Purines and -Pyrimidines As Antiviral Agents | TPMT, HPRT1, MTAP | ATM 4606/4885POLB 363/4885SMN1; SMN2 1963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.