Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740325 | 0.90 | POLB (0.40) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL3147434 | 0.84 | POLB (0.46) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL8653250 | 0.83 | POLB (0.41) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL3133383 | 0.83 | ATM (0.46) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL8995766 | 0.81 | POLB (0.43) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL21192369 | 0.79 | MEN1 (0.33) | POLBATMMEN1KMT2AKDM4E | |
| SCHEMBL15070910 | 0.78 | POLB (0.41) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL18134201 | 0.78 | ALDH1A1 (0.46) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL69496 | 0.78 | ALDH1A1 (0.46) | POLBATMALDH1A1ALOX15MEN1 | |
| SCHEMBL10427679 | 0.78 | BRD4 (0.43) | POLBMEN1KMT2ABRD4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220219155-A1 | Compositions And Methods For Visible-Light-Controlled Ruthenium-Catalyzed Olefin Metathesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2022-07-14 | — | — | US | disclosed |
| US-20220161245-A1 | Compositions And Methods For Infrared-Light-Controlled Ruthenium-Catalyzed Olefin Metathesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2022-05-26 | — | — | US | disclosed |
| US-20210237045-A1 | USE OF N-CHELATING RUTHENIUM COMPLEXES IN THE METATHESIS REACTION | APEIRON SYNTHESIS S.A. (PL) | 2021-08-05 | — | — | US | disclosed |
| EP-3068768-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2019-07-31 | — | — | EP | disclosed |
| EP-3068768-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2019-07-31 | — | — | EP | disclosed |
| US-20180065914-A1 | RUTHENIUM POLYMERISATION CATALYSTS | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2018-03-08 | — | — | US | disclosed |
| US-9815765-B2 | Ruthenium polymerisation catalysts | UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 2017-11-14 | — | — | US | disclosed |
| US-9776178-B2 | Ruthenium complexes comprising an asymmetrical unsaturated N-heterocyclic diaminocarbene | ECOLE NATIONALE SUPERIEURE DE CHIMIE DE RENNES (FR) | 2017-10-03 | — | — | US | disclosed |
| US-20170145152-A1 | GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN METATHESIS REACTION | GUANG MING INNOVATION COMPANY (WUHAN) (CN) | 2017-05-25 | — | — | US | disclosed |
| EP-3068768-A1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2016-09-21 | — | — | EP | disclosed |
| US-8361922-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| WO-2012116695-A1 | MOLYBDENUM AND TUNGSTEN METAL COMPLEXES AND USE THEREOF AS PRECATALYSTS FOR OLEFIN METATHESIS | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2012-09-07 | — | — | WO | disclosed |
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2012-05-17 | — | — | US | disclosed |
| US-8008224-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008224-B2 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | MATERIA, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2007-12-06 | — | — | US | disclosed |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2007-12-06 | — | — | US | disclosed |
| WO-2007075427-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | MATERIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| EP-1743899-A1 | Metal complexes for use in metathesis, atom transfer radical reactions, addition polymerisation and vinylation reactions, methods and intermediates for making them | Universiteit Gent (BE) | 2007-01-17 | — | — | EP | disclosed |
| EP-1468004-B1 | METAL COMPLEXES FOR USE IN METATHESIS | UNIV GENT (BE) | 2006-12-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123133-A1 | ORGANOMETALLIC RUTHENIUM COMPLEXES AND RELATED METHODS FOR THE PREPARATION OF TETRA-SUBSTITUTED AND OTHER HINDERED OLEFINS | ORC3, OXER1, CBR3 | POLB 2244/4885ATM 1880/4885ALDH1A1 2951/4885 |
| US-20210237045-A1 | USE OF N-CHELATING RUTHENIUM COMPLEXES IN THE METATHESIS REACTION | CYC1, AP1M1, HNMT | POLB 575/4885ATM 3706/4885ALDH1A1 1856/4885 |
| US-20070282148-A1 | Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins | ORC3, OXER1, CBR3 | POLB 2244/4885ATM 1880/4885ALDH1A1 2951/4885 |
| US-20170145152-A1 | GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN METATHESIS REACTION | F8, COASY, FADS1 | POLB 3132/4885ATM 3514/4885ALDH1A1 1858/4885 |
| US-20220161245-A1 | Compositions And Methods For Infrared-Light-Controlled Ruthenium-Catalyzed Olefin Metathesis | CYBB, CYBA, CYB5R3 | POLB 322/4885ATM 491/4885ALDH1A1 714/4885 |
| US-20180065914-A1 | RUTHENIUM POLYMERISATION CATALYSTS | RRP12, PCBP1, PARG | POLB 309/4885ATM 1741/4885ALDH1A1 4132/4885 |
| US-20220219155-A1 | Compositions And Methods For Visible-Light-Controlled Ruthenium-Catalyzed Olefin Metathesis | PPOX, CYBA, CYBB | POLB 316/4885ATM 545/4885ALDH1A1 1395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.