Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SQOR | Q9Y6N5 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623647 | 0.83 | L3MBTL1 (0.54) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL13360776 | 0.83 | ADORA1 (0.66) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL19665208 | 0.82 | ADORA1 (0.54) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL29444600 | 0.82 | ADORA1 (0.54) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL5218636 | 0.73 | L3MBTL1 (0.71) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL22785937 | 0.73 | ADORA1 (0.51) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL1162737 | 0.73 | SQOR (0.47) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL31350444 | 0.71 | ALDH1A1 (0.68) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL31518981 | 0.70 | ADORA1 (0.56) | ADORA1ADORA2AL3MBTL1MAPK1SQOR | |
| SCHEMBL12679759 | 0.69 | ADORA1 (0.55) | ADORA1ADORA2AL3MBTL1MAPK1SQOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113415-A1 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER | MERCK SHARP & DOHME CORP | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113415-A1 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER | EPHA4, EPHA1, ERBB4 | ADORA1 377/4885ADORA2A 583/4885L3MBTL1 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.