Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13367228 | 0.86 | MAPT (0.39) | LMNAKDM4ENPC1RAB9AGAA | |
| SCHEMBL27168782 | 0.82 | GAA (0.43) | KDM5BKDM4EHSD17B10RXFP1ADORA3 | |
| SCHEMBL12225744 | 0.81 | ADORA2A (0.39) | KDM5BGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3416727 | 0.80 | KMT2A (0.46) | LMNAGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL16350295 | 0.77 | CYP3A4 (0.36) | LMNAGAAL3MBTL1 | |
| SCHEMBL4026168 | 0.75 | KDM5B (0.42) | KDM5BGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL13367230 | 0.75 | LMNA (0.44) | KDM5BLMNAGABRA1GABRG2GABRB3 | |
| SCHEMBL4031544 | 0.74 | KDM5B (0.45) | KDM5BGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12225690 | 0.74 | PKM (0.38) | LMNAKDM4ENPC1RAB9AGAA | |
| SCHEMBL27275782 | 0.72 | KDM5B (0.40) | KDM5BGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718781-B2 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-18 | — | — | US | disclosed |