Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.62 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13368541 | 0.90 | HTR6 (0.60) | HTR6ALDH1A1LMNAPKMTP53 | |
| SCHEMBL13368613 | 0.90 | HTR6 (0.59) | HTR6ALDH1A1LMNATP53HTT | |
| SCHEMBL13964525 | 0.88 | HTR6 (0.64) | HTR6KDM2BALDH1A1LMNACYP11B1 | |
| SCHEMBL13964315 | 0.84 | HTR6 (0.64) | HTR6KDM2BALDH1A1LMNAPKM | |
| SCHEMBL13368644 | 0.82 | HTR6 (0.52) | HTR6ALDH1A1LMNAPKMHPGD | |
| SCHEMBL13947148 | 0.82 | HTR6 (0.62) | HTR6KDM2BALDH1A1PKMCYP11B1 | |
| SCHEMBL13964526 | 0.81 | HTR6 (0.63) | HTR6ALDH1A1TP53HTTNPSR1 | |
| SCHEMBL13964855 | 0.80 | HTR6 (0.56) | HTR6ALDH1A1PKMSMN1; SMN2HTT | |
| SCHEMBL13368612 | 0.79 | HTR6 (0.58) | HTR6ALDH1A1LMNAPKMTP53 | |
| SCHEMBL13368645 | 0.79 | RORC (0.51) | HTR6KDM2BRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723374-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-7476746-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-01-13 | — | — | US | disclosed |