Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23512823 | 1.00 | POLB (0.49) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL1336860 | 1.00 | POLB (0.49) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL18970299 | 0.96 | POLB (0.49) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL4926941 | 0.90 | ALDH1A1 (0.46) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL8321789 | 0.88 | ALDH1A1 (0.58) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL26253773 | 0.88 | ALDH1A1 (0.58) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL6227253 | 0.88 | POLB (0.54) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL21936369 | 0.86 | POLB (0.53) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL28594973 | 0.82 | PNP (0.53) | POLBALDH1A1MAPTGAAMAPK1 | |
| SCHEMBL7193663 | 0.82 | POLB (0.50) | POLBALDH1A1MAPTGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260028356-A1 | 1,3,4,7-TETRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZEPINE BCL-2 INHIBITORS | ABBVIE INC (US) | 2026-01-29 | — | — | US | disclosed |
| US-20250066388-A1 | 1,3,4,7-TETRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZEPINE BCL-2 INHIBITORS | ABBVIE INC (US) | 2025-02-27 | — | — | US | disclosed |
| US-11964990-B2 | 1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[2,3-b][1,4]oxazepine bcl-2 inhibitors | ABBVIE INC. (US) | 2024-04-23 | — | — | US | disclosed |
| US-20230234971-A1 | 1,3,4,7-Tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[2,3-b][1,4]oxazepine Bcl-2 Inhibitors | ABBVIE INC. (US) | 2023-07-27 | — | — | US | disclosed |
| WO-2023141536-A1 | 1,3,4,7-TETRAHYDRO-2H-PYRROLO [3',2':5,6] PYRIDO[2,3-B] [1,4] OXAZEPINE BC1-2 INHIBITORS | ABBVIE INC. (US) | 2023-07-27 | — | — | WO | disclosed |
| EP-4073051-A1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF OXETAN-2-YLMETHANAMINE | Eli Lilly and Company (US) | 2022-10-19 | — | — | EP | disclosed |
| CN-114728923-A | Process and intermediates for the preparation of oxetan-2-ylmethylamines | 伊莱利利公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-110035745-B | Small molecule AMPK activators | 匹兹堡大学联邦系统高等教育 | 2022-04-29 | — | — | CN | disclosed |
| WO-2021118906-A1 | PROCESS AND INTERMEDIATE FOR THE PREPARATION OF OXETAN-2-YLMETHANAMINE | ELI LILLY AND COMPANY (US) | 2021-06-17 | — | — | WO | disclosed |
| EP-3013907-B1 | PARTICLE OF MODIFIED SILICA | NOURYON CHEMICALS INT BV (NL) | 2019-08-28 | — | — | EP | disclosed |
| EP-2388251-B1 | METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF | LIANHE CHEMICAL TECHNOLOGY CO LTD (CN) | 2013-08-28 | — | — | EP | disclosed |
| WO-2013046211-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF | SYMED LABS LIMITED (IN) | 2013-04-04 | — | — | WO | disclosed |
| CN-102351807-A | Dibenzyl-1,3-oxazolidine-2-ketone compound and preparation method and application thereof | UNIV SICHUAN | 2012-02-15 | — | — | CN | disclosed |
| EP-2388251-A1 | METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF | Lianhe Chemical Technology Co., Ltd. (CN) | 2011-11-23 | — | — | EP | disclosed |
| US-20110275805-A1 | METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF | LIANHE CHEMICAL TECHNOLOGY CO., LTD. (CN) | 2011-11-10 | — | — | US | disclosed |
| US-8038543-B2 | Golf swing training device | CAPESIUS DEAN C | 2011-10-18 | — | — | US | disclosed |
| US-4659721-A | GASTROINTESTINAL DISORDER, HISTAMINE H2-ANTOGONISTS | LUDWIG HEUMANN & CO. GMBH (DE) | 1987-04-21 | — | — | US | disclosed |
| US-4656180-A | HISTAMINE-H2 RECEPTORS; ANTIULCER AGENTS | LUDWIG HEUMANN & CO., GMBH (DE) | 1987-04-07 | — | — | US | disclosed |
| EP-0158789-A1 | Diamine derivatives, process for their preparation and medicines containing these compounds | LUDWIG HEUMANN & CO GMBH (DE) | 1985-10-23 | — | — | EP | disclosed |
| EP-0154721-A1 | Alcanol derivatives, processes for their preparation and medicines containing these compounds | LUDWIG HEUMANN & CO GMBH (DE) | 1985-09-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260028356-A1 | 1,3,4,7-TETRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZEPINE BCL-2 INHIBITORS | BCL9L, BCL2L2, BCL2L1 | POLB 3669/4885ALDH1A1 1491/4885MAPT 4241/4885 |
| US-20250066388-A1 | 1,3,4,7-TETRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZEPINE BCL-2 INHIBITORS | BCL9L, BCL2L1, BCL2L2 | POLB 2788/4885ALDH1A1 912/4885MAPT 4485/4885 |
| US-20230234971-A1 | 1,3,4,7-Tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[2,3-b][1,4]oxazepine Bcl-2 Inhibitors | BCL9L, BCL2L1, BCL2L2 | POLB 2788/4885ALDH1A1 912/4885MAPT 4485/4885 |
| US-11964990-B2 | 1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[2,3-b][1,4]oxazepine bcl-2 inhibitors | BCL9L, BCL2L1, BCL9 | POLB 2728/4885ALDH1A1 920/4885MAPT 4499/4885 |
| US-20110275805-A1 | METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF | HDAC9, KAT5, ACMSD | POLB 281/4885ALDH1A1 361/4885MAPT 2937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.