Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18175980 | 0.84 | PBRM1 (0.49) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL24766663 | 0.81 | PBRM1 (0.46) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL1172823 | 0.79 | PBRM1 (0.55) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL13008135 | 0.79 | CES2 (0.55) | GABRA1GABRB2LMNANPC1ALDH1A1 | |
| SCHEMBL29480879 | 0.79 | CES2 (0.55) | GABRA1GABRB2LMNANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27784476 | 0.78 | PBRM1 (0.53) | PBRM1LMNANPC1MITFPOLB | |
| Hydrochloric Acid SCHEMBL29512126 | 0.77 | CES2 (0.53) | GABRA1GABRB2LMNAALDH1A1HPGD | |
| SCHEMBL8035994 | 0.77 | NPSR1 (0.54) | GABRA1GABRB2LMNANPC1POLB | |
| SCHEMBL458409 | 0.77 | NPSR1 (0.59) | GABRA1GABRB2LMNAALDH1A1HPGD | |
| SCHEMBL2955528 | 0.76 | HPGD (0.50) | GABRA1GABRB2LMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2014285-B1 | NPYY5 antagonists | SHIONOGI & CO (JP) | 2010-05-05 | — | — | EP | disclosed |
| EP-1249233-B9 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2009-08-05 | — | — | EP | disclosed |
| EP-2014285-A1 | NPYY5 antagonists | Shionogi&Co., Ltd. (JP) | 2009-01-14 | — | — | EP | disclosed |
| EP-1249233-B1 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |
| CN-1944398-A | New benzoyl amide compounds and its preparing method and medicine use | INST OF MEDICINES CHINESE ACAD (CN) | 2007-04-11 | — | — | CN | disclosed |