Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13372550 | 0.90 | MEN1 (0.57) | METMAOBMEN1KMT2AALDH1A1 | |
| SCHEMBL13473004 | 0.87 | SMN1; SMN2 (0.46) | METC5AR1MEN1KMT2AALDH1A1 | |
| SCHEMBL13372549 | 0.87 | MET (0.55) | METLRRK2C5AR1MAOBMEN1 | |
| SCHEMBL13372613 | 0.87 | LRRK2 (0.52) | METLRRK2C5AR1MEN1KMT2A | |
| SCHEMBL4943478 | 0.83 | MET (0.74) | METLRRK2MEN1KMT2A | |
| SCHEMBL13372551 | 0.83 | RAB9A (0.48) | C5AR1MAOBMEN1KMT2AALDH1A1 | |
| SCHEMBL4940769 | 0.74 | SGMS2 (0.66) | METLRRK2MEN1KMT2AALDH1A1 | |
| SCHEMBL28025308 | 0.73 | MEN1 (0.55) | MAOBMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL1650152 | 0.72 | LRRK2 (0.77) | METLRRK2MEN1KMT2AALDH1A1 | |
| SCHEMBL5108858 | 0.71 | USP2 (0.56) | LRRK2MAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853570-B1 | HSP90-INHIBITING TRIAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |