Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 3/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29709289 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1337914 | 0.94 | KDM4E (0.48) | SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1336501 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1337828 | 0.88 | TP53 (0.47) | DHODHKMT2AKDM4EMEN1 | |
| SCHEMBL1336472 | 0.84 | KDM4E (0.53) | SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1336932 | 0.82 | NR4A2 (0.44) | DHODHNR4A2KMT2AMEN1 | |
| SCHEMBL1337509 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1335619 | 0.81 | ALDH1A1 (0.40) | CYP2C9CYP2C19KMT2ARPS6KA3FFAR4 | |
| SCHEMBL197506 | 0.78 | CYP19A1 (0.64) | SMN1; SMN2CYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1335616 | 0.78 | TP53 (0.54) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220387362-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | RHIZEN PHARMACEUTICALS AG (CH) | 2022-12-08 | — | — | US | disclosed |
| EP-4048251-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | Rhizen Pharmaceuticals AG (CH) | 2022-08-31 | — | — | EP | disclosed |
| CN-114828842-A | Composition comprising DHODH inhibitor for the treatment of acute myeloid leukemia | 理森制药股份公司 | 2022-07-29 | — | — | CN | disclosed |
| WO-2021079273-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | RHIZEN PHARMACEUTICALS AG (CH) | 2021-04-29 | — | — | WO | disclosed |
| US-9758474-B2 | Immunomodulator and anti-inflammatory compounds | INCOZEN THERAPEUTICS PVT. LTD. (IN) | 2017-09-12 | — | — | US | disclosed |
| US-20140220050-A1 | NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS | INCOZEN THERAPEUTICS PVT. LTD. (CH) | 2014-08-07 | — | — | US | disclosed |
| US-20110275603-A1 | NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS | RHIZEN PHARMACEUTICALS SA (FR) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140220050-A1 | NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS | DHODH, DLD, DHFR | SMN1; SMN2 4665/4885CYP1A2 1449/4885CYP19A1 1334/4885 |
| US-20110275603-A1 | NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS | DHODH, DLD, DHFR | SMN1; SMN2 4665/4885CYP1A2 1449/4885CYP19A1 1334/4885 |
| US-20220387362-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | DHODH, FLT3, IDH3A | SMN1; SMN2 4548/4885CYP1A2 1000/4885CYP19A1 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.