Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111568 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL14091323 | 0.79 | SMN1; SMN2 (0.67) | HTTSMN1; SMN2ALDH1A1POLBKDM4E | |
| SCHEMBL30464453 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL23742722 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL19657112 | 0.77 | HTT (0.47) | HTTSMN1; SMN2ALDH1A1POLBKDM4E | |
| SCHEMBL19657110 | 0.74 | ACACB (0.53) | SMN1; SMN2ALDH1A1POLBKDM4EMAPT | |
| SCHEMBL1871362 | 0.74 | RAB9A (0.46) | HTTSMN1; SMN2ALDH1A1POLBKDM4E | |
| SCHEMBL13373349 | 0.74 | NPC1 (0.52) | SMN1; SMN2LMNACNR2 | |
| SCHEMBL27738314 | 0.73 | HTT (0.58) | HTTSMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL17758496 | 0.72 | BRD4 (0.47) | HTTSMN1; SMN2KDM4EMAPTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |